Aging is characterized by inflammation, glycation and mitochondrial decay. Life Extension members now have access to a state-of-the-art nutritional formula called Mitochondrial Energy Optimizer with BioPQQ™ that not only protects delicate cellular structures and enables cells to perform life-sustaining metabolic processes … it also helps generate new mitochondria! This formula is designed to counteract age-related structural and functional changes and promote biogenesis with these unique ingredients:

• PQQ (Pyrroloquinoline quinone) — this next generation cellular rejuvenator triggers growth of new mitochondria in aging cells10 … and activates genes involved in protecting delicate structures within the mitochondria.11-14
• Carnosine — As humans age, their proteins become irreversibly damaged by lethal glycation reactions. Glycation is the cross-linking of proteins and sugar to form non-functioning structures in the body, which can lead to alterations of normal cell function. Carnosine is not only the premier anti-glycating agent, but it also protects neurons against reactive and cytotoxic protein carbonyl species associated with normal aging.15-19
• Luteolin — Unremitting systemic inflammation is involved with virtually every undesirable consequence of aging. Culprits behind chronic inflammatory reactions are pro-inflammatory cytokines, such as interleukin-1 and tumor necrosis factor alpha. Luteolin is a super-potent plant extract that has been shown to suppress these dangerous inflammatory cytokines.20-26
• Benfotiamine — Benfotiamine blocks multiple destructive biochemical pathways, including AGEs’ formation pathway, which is induced by higher than desirable blood glucose levels. Human mortality studies indicate that ideal fasting glucose levels are between 74–85 mg/dL. Yet many aging people have fasting glucose above 90 mg/dL, which is less than optimal.27-29 Benfotiamine can activate glucose metabolism and promote already healthy blood glucose levels. In addition, benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage.30
• Pyridoxal 5’-Phosphate — Aging results in the formation of toxic advanced glycation end products throughout the body. Pyridoxal 5’-phosphate is the active form of vitamin B6 that has been shown to protect against both lipid and protein glycation reactions.31-33
• R-Lipoic Acid — Destructive free radical activity in the mitochondria plays a major role in the loss of cellular vitality. The microencapsulated Bio-Enhanced® R-lipoic acid facilitates youthful mitochondrial energy output while guarding against free radicals. Two forms of lipoic acid are sold on the supplement market, but R-lipoic acid is far more potent.34-39
• Acetyl-L-Carnitine Arginate — The amino acid L-carnitine is required to transport fats into the mitochondria to be burned for cellular energy. ArginoCarn® Acetyl-L-carnitine arginate is a patented form of carnitine that has been shown in cell cultures to stimulate the growth of neurites.40-42

Taking all of these ingredients separately would be prohibitively expensive. Life Extension members can benefit from all of them in this one cost-effective, comprehensive formulation to promote mitochondrial structure, function and formation.

Bio-Enhanced® is a registered trademark of Geronova Research, Inc. Pureolin™ is a trademark of Pharma Science Nutrients, Inc., and is used here under license. All rights reserved worldwide. BioPQQ™ is a trademark of MGC (Japan). ArginoCarn® is a registered trademark of Sigma-tau HealthSciences, Inc. and is protected by US patents 6,365,622, US 6,703,042 and EP1202956.